Amphetamin synthese pdf

The invention relates to a process for preparing acylated amphetamine, methamphetamine and dexamphetamine derivatives by reacting the parent amine with the to be coupled acid or a salt of the to be coupled acid which acid is protected or not protected, in the presence of an alkylphosphonic acid anhydride as coupling agent and - provided the acid (V2) was protected - the cleavage of the

Amphetamine (contracted from alpha-methylphenethylamine) is a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. Amphetamine was discovered in 1887 and exists as two enantiomers: levoamphetamine and dextroamphetamine. Amphetamine is a synthetic substance related to natural sympathomimetic amines. Amphetamine appears to exert its central nervous system (CNS) and peripheral effects indirectly by inducing the release of biogenic amines from their storage sites in nerve terminals. The invention relates to processes for preparing acylated amphetamine, methamphetamine and dexamphetamine derivatives by reacting the parent amine with the to be-coupled acid or a salt of the to-be coupled acid which acid is optionally protected, in the presence of an alkylphosphonic acid anhydride as coupling agent and, if the acid was protected then cleaving the protecting group(s), in a one Amphetamine sulphate synthesis . What we are need is: 5g P2NP 50ml Isopropanol 7,5-8,5g of Aliuminium foil (better to use thick foil) 50ml 98% acetic acid (can also use 70%, than dont need water) 50g NaOH 1ml H2SO4 Firstly, you will make mix with acetic acid and water.Water we need, because we are using 98% of acetic.If will be 70%, than we will not need.Pour (50ml GAA + 25ml dH2O) in to 250ml Comprehensive Leuckart Reaction Overview from Organic Reactions (PDF) Synthesis of Allylbenzene and Phenyl-2-bromopropane; Direct Amination of Phenylpropenes to Amphetamines (German PDF) Preparation of Amphetamines fro